Do not use meropenem if you dont understand all instructions for proper use. The mean apache ii score was slightly higher in the meropenem group than in the imipenemcilastatin group, as was the number of patients who had received previous antibacterial therapy. Meropenem is a recently developed carbapenem antibiotic, similar to imipenem, with a wide spectrum of activity against grampositive and gramnegative bacteria. May 25, 2017 medicine a broadspectrum betalactam antibiotic used to treat meningitis and pneumonia.
In comparison with imipenem, meropenem is relatively stable to hydrolysis by the enzyme dehydropeptidase i dhpi, thus precluding the need for coadministration with an inhibitor of dhpi, such as cilastatin. Meropenem bactericidal activity depends on the time when the free drug concentrations remain above the minimum inhibitory concentration of pathogens. Dailymed meropenem injection, powder, for solution. The dry powder should be stored at controlled room temperature 20. Monographs for commonly administered intravenous medications. Meropenem merrem is an injectable antibiotic prescribed to treat a variety of bacteria. Meropenem is a topic covered in the harriet lane handbook to view the entire topic, please sign in or purchase a subscription the harriet lane handbook app and website provides pediatric diagnosis and treatment, pediatric management algorithms, and pediatric drug formulary from experts at johns hopkins university.
Meropenem dosing and therapeutic interchange policy implemented. For the fda primary end point, overall success occurred in 189 of 192 98. Higher doses of meropenem are recommended for treating pseudomonas infections in order to. Meropenem is a carbapenem antibacterial agent with a broad spectrum of activity which encompasses gramnegative, grampositive and anaerobic bacteria. This medication is good for only 5 days after mixing when stored in the refrigerator and protected from light. Merrem meropenem is an antibiotic thats usually only given in the hospital for serious infections. Read and carefully follow any instructions for use provided with your medicine. Know meropenem 500 mg injection uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions. Meropenem is an antibiotic with wide antibacterial coverage. Doripenem vs meropenem against pseudomonas and acinetobacter. Pdf meropenemvaborbactam in the treatment of acute.
Merrem meropenem is only available as an injectable, so its usually only given for serious infections. Doripenem is a new parenteral antibiotic from the carbapenem class. Its chiral tetrahydrofuran substituent at position c2 is responsible for its improved chemical stability and reduced cns effects. Mar 29, 2020 a mother received meropenem 1 gram iv every 8 hours for 7 days while exclusively breastfeeding her newborn. Meropenem in the treatment of complicated skin and soft. Feb 05, 2012 effect of piptazo vs meropenem on mortality in gramnegative bloodstream infection duration. Meropenem is a member of the antibiotic class of carbapenems, which are broadspectrum antibiotics that possess activity against several. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and.
Doses of 1 gram may also be administered as an intravenous bolus injection 5 ml to 20 ml over approximately 3 minutes to 5 minutes. In order to reconstitute this medication, you will need the following. When questioned later, she stated that her infant had no oral thrush, watery diarrhea, or diaper dermatitis that required antifungal therapy. Neomero1, an open label, randomised, comparator controlled, superiority trial aims to compare the. Meropenem for injection is indicated as a single agent therapy for the treatment of bacterial meningitis caused by streptococcus pneumoniae, haemophilus influenzae, and neisseria meningitidis. Meropenem is a relatively new drug and more studies need to be published before susceptibilities of one carbapenem can be used to predict the other. Monographs for commonly administered intravenous medications in home and community care 1 p a g e meropenem 1drug class antibiotic carbapenem spectrum1,2 refer to product monograph for complete spectrum staphylococcus aureus, group d strep, aerobic gram negative acinetobacter species, citrobacter species, enterobacter cloacae, haemophilus influenza, escherichia coli.
Meropenem is slightly more active than imipenem against gramnegative organisms. Article information, pdf download for stability of meropenem after reconstitution for. Download fulltext pdf imipenem and meropenemresistant mutants of enterobacter cloacae and proteus rettgeri lack porins article pdf available in antimicrobial agents and chemotherapy 356. Meropenem is a member of the carbapenems drug class and is commonly used for intraabdominal infection, meningitis, nosocomial pneumonia, and others. Meropenem is a carbapenem antibiotic with broad spectrum of activity that is administered intravenously and used for severe bacterial infections due to sensitive agents.
May have cross sensitivities with cephalosporin, penicillin or other beta lactam. The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem is also used to treat bacterial meningitis infection that causes inflammation of the tissue that covers the brain and spinal cord meropenem may also be used for purposes not listed in this medication guide. There is limited safety data available to support the administration of a 40 mgkg up to a maximum of. Meropenem is a topic covered in the harriet lane handbook to view the entire topic, please sign in or purchase a subscription the harriet lane handbook app and website provides pediatric diagnosis and treatment, pediatric management algorithms, and pediatric drug formulary from experts at. The demographic and baseline clinical characteristics of the two groups were similar. Merrem iv powder for intravenous injection or infusion is presented as a sterile white powder containing meropenem trihydrate equivalent to. Single dose minibags can be infused over 1530 minutes. Highlights of prescribing information these highlights do not. Like other carbapenems, meropenem is stable against chromosomal and extendedspectrum. Meropenem and doripenem are thought to be the more potent in vitro agents against gram negative organisms. Meropenem vs standard of care for treatment of late.
Meropenem must be mixed with a liquid diluent before using it. The dry powder should be stored at controlled room temperature 2025c 6877f see usp. A 67yearold man developed serratia marcescens peritonitis within a week of commencing peritoneal dialysis. However, mic 50 and mic 90 were same for both the drugs against a. Meropenem penetrates the cell wall of most grampositive and gramnegative bacteria to bind penicillinbindingprotein pbp targets.
Among corynebacterium jeikeium, strains were encountered that showed susceptibility to meropenem but resistance to imipenem and other j lactams. Merrem iv is supplied in 20 ml and 30 ml injection vials containing sufficient meropenem to deliver 500 mg or 1 gram for intravenous administration, respectively. Laboratory detection of imipenem or meropenem resistance. Meropenem is a common cause of mild transient aminotransferase elevations and can rarely result in clinically apparent, cholestatic liver injury. Meronem iv 500mg summary of product characteristics. This unusual case highlights the problem of multidrugresistant peritoneal dialysis infections and the potential viability of intraperitoneal meropenem as. It is given by injection into a vein common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Meropenem versus imipenemcilastatin as empirical monotherapy. Compared with imipenem, meropenem and doripenem, the spectrum of activity of ertapenem is more limited primarily because it lacks activity against.
It should be used with caution in patients with central nervous system disorders. Effect of piptazo vs meropenem on mortality in gramnegative bloodstream infection duration. Meropenem is a broadspectrum carbapenem antibiotic with excellent activity against many pathogens associated with complicated skin and soft tissue infections csstis. Composicion, indicaciones, presentacion y contraindicaciones. Clinical trials comparing imipenem with meropenem, or either imipenem or meropenem with standard therapy in the treatment of serious infections were.
Randomized trial of ceftazidimeavibactam vs meropenem for. Effect of piperacillintazobactam vs meropenem on 30day. Meropenem, sold under the brandname merrem among others, is a broadspectrum antibiotic used to treat a variety of bacterial infections. Meropenem binds to pbps 2, 3 and 4 of escherichia coli and pseudomonas aeruginosa. In an open randomised multicentre trial the efficacy clinical and bacteriological and safety of empirical monotherapy with meropenem mem. Meropenem is a parenteral carbapenem antibiotic which has a broad spectrum of activity against aerobes and anaerobes. A mother received meropenem 1 gram iv every 8 hours for 7 days while exclusively breastfeeding her newborn. Meropenem for injection is supplied in 20 ml and 30 ml injection vials containing sufficient meropenem to deliver 500 mg or 1 gram for intravenous administration, respectively. Meropenem 500 mg injection uses, dosage, side effects. Its antimicrobial spectrum more closely resembles those of meropenem and imipenem than that of ertapenem. May 17, 2019 meropenem for injection is supplied in 20 ml and 30 ml injection vials containing sufficient meropenem to deliver 500 mg or 1 gram for intravenous administration, respectively.
A multicenter, openlabel, randomized, parallelgroup trial was conducted in belgium, evaluating empirical monotherapy with meropenem or imipenemcilastatin both 1 g8 h intravenously in icu patients with one or more of the following infections caused by sensitive pathogens. Meropenem has been shown to penetrate well into several body fluids and tissues. Vabomere meropenem and vaborbactam is indicated for the treatment of patients 18 years of age and older with complicated urinary tract infections cuti including pyelonephritis caused by the following susceptible microorganisms. Oct 22, 2019 the bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Monographs for commonly administered intravenous medications in home and community care 2 p a g e meropenem administration2,4,5 can be dispensed as single doses and administered by gravity or pole pump with each nursing visit. Ask your doctor or pharmacist if you have questions. Mar 31, 2014 effect of piptazo vs meropenem on mortality in gramnegative bloodstream infection duration.
Meropenem reconstitution instructions 500 mg vial your pet was prescribed meropenem, a liquid intravenous antibiotic for infections. When questioned later, she stated that her infant had no oral thrush, watery diarrhea, or diaper dermatitis that required antifungal therapy during the month following her meropenem therapy. Meropenem is metabolised by hydrolysis of the betalactam ring generating a microbiologically inactive metabolite. Meropenem is a carbapenem antibiotic structurally related to imipenem, but reportedly with less seizure proclivity. By continuing to browse this site you are agreeing to our use of cookies. It can be given at home, but youll have to be taught how to inject it correctly. Find out what health conditions may be a health risk when taken with meropenem intravenous. Meropenem 500 mg injection is a broad spectrum antibiotic used to treat a variety of conditions caused by bacteria such as infections of stomach, brain, and lungs.
Some of these include meningitis, intraabdominal infection, pneumonia, sepsis, and anthrax. Webmd provides common contraindications for meropenem intravenous. Doripenem was more effective as compared to meropenem against p. In patients with moderate to severe intraabdominal infections, empirical mono therapy with meropenem achieved. Thus, it has significant in vitro activity against streptococci, methicillinsusceptible staphylococci, enterobacteriaceae including extendedspectrum bdoripenem has been approved by fda in 2007 for the treatment of. The advantage of it over standard of care could be its wider antibacterial coverage and thus the use of monoinstead of combination therapy. This meropenem price guide is based on using the discount card which is accepted at most u. Any isolate that tested either i or r to at least 1 of these.
Taj all products view products according to category. Faropenem medoxomil is a new orally administered penem antibiotic. Escherichia coli, klebsiella pneumoniae, and enterobacter cloacae species complex. Meropenem indicaciones, dosificacion, presentacion, efectos.
Meropenem is used to treat severe infections of the skin or stomach. Stability of meropenem after reconstitution for administration by. Activity of meropenem, against grampositive bacteria core. Meropenem for injection should be given as intravenous infusion over approximately 15 minutes to 30 minutes or as an intravenous bolus injection 5 ml to 20 ml over approximately 3 minutes to 5 minutes. The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin non. The goal of this study was to compare clinical and bacteriological efficacy of continuous meropenem infusion versus bolus administration in critically ill patients with severe infection, and to evaluate the safety of both dosing regimens. Pronunciation of meropenem with 2 audio pronunciations, 4 translations and more for meropenem. A total of 212 patients entered the study, 107 in the meropenem group and 105 in the imipenemcilastatin group. At least three studies have shown meropenem to have good clinical efficacy and to. For intravenous use only 500 mg per vial 10 x 500 mg sterile vials 7012114537 meropenem for injection, usp i.
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